Population Pharmacokinetics of High-Dose Continuous-Infusion Meropenem and Considerations for Use in the Treatment of Infections Due to KPC-Producing Klebsiella pneumoniae

We assessed the population pharmacokinetics of high-dose continuous-infusion (HDCI) meropenem in a cohort of patients with Klebsiella pneumoniae carbapenemase (KPC)-producing Klebsiella pneumoniae (KPC-Kp) infections. Monte Carlo simulations were used to define the permissible HDCI meropenem regimen...

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Detalhes bibliográficos
Publicado no:Antimicrob Agents Chemother
Main Authors: Cojutti, Piergiorgio, Sartor, Assunta, Righi, Elda, Scarparo, Claudio, Bassetti, Matteo, Pea, Federico
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2017
Assuntos:
Clinical Therapeutics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5610526/
https://ncbi.nlm.nih.gov/pubmed/28760900
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00794-17
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