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Deletion of sigB Causes Increased Sensitivity to para-Aminosalicylic Acid and Sulfamethoxazole in Mycobacterium tuberculosis

Although the de novo folate biosynthesis pathway has been well studied in bacteria, little is known about its regulation. In the present study, the sigB gene in Mycobacterium tuberculosis was deleted. Subsequent drug susceptibility tests revealed that the M. tuberculosis ΔsigB strain was more sensit...

תיאור מלא

שמור ב:
מידע ביבליוגרפי
הוצא לאור ב:Antimicrob Agents Chemother
Main Authors: Yang, Shan-Shan, Hu, Yang-Bo, Wang, Xu-De, Gao, Yun-Rong, Li, Kun, Zhang, Xian-En, Chen, Shi-Yun, Zhang, Tian-Yu, Gu, Jing, Deng, Jiao-Yu
פורמט: Artigo
שפה:Inglês
יצא לאור: American Society for Microbiology 2017
נושאים:
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC5610497/
https://ncbi.nlm.nih.gov/pubmed/28717039
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00551-17
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