Deletion of sigB Causes Increased Sensitivity to para-Aminosalicylic Acid and Sulfamethoxazole in Mycobacterium tuberculosis

Although the de novo folate biosynthesis pathway has been well studied in bacteria, little is known about its regulation. In the present study, the sigB gene in Mycobacterium tuberculosis was deleted. Subsequent drug susceptibility tests revealed that the M. tuberculosis ΔsigB strain was more sensit...

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Detaylı Bibliyografya
Yayımlandı:Antimicrob Agents Chemother
Asıl Yazarlar: Yang, Shan-Shan, Hu, Yang-Bo, Wang, Xu-De, Gao, Yun-Rong, Li, Kun, Zhang, Xian-En, Chen, Shi-Yun, Zhang, Tian-Yu, Gu, Jing, Deng, Jiao-Yu
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: American Society for Microbiology 2017
Konular:
Susceptibility
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC5610497/
https://ncbi.nlm.nih.gov/pubmed/28717039
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00551-17
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