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Deletion of sigB Causes Increased Sensitivity to para-Aminosalicylic Acid and Sulfamethoxazole in Mycobacterium tuberculosis

Although the de novo folate biosynthesis pathway has been well studied in bacteria, little is known about its regulation. In the present study, the sigB gene in Mycobacterium tuberculosis was deleted. Subsequent drug susceptibility tests revealed that the M. tuberculosis ΔsigB strain was more sensit...

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Bibliografski detalji
Izdano u:Antimicrob Agents Chemother
Glavni autori: Yang, Shan-Shan, Hu, Yang-Bo, Wang, Xu-De, Gao, Yun-Rong, Li, Kun, Zhang, Xian-En, Chen, Shi-Yun, Zhang, Tian-Yu, Gu, Jing, Deng, Jiao-Yu
Format: Artigo
Jezik:Inglês
Izdano: American Society for Microbiology 2017
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Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5610497/
https://ncbi.nlm.nih.gov/pubmed/28717039
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00551-17
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