Unique binding modes for the broad neutralizing activity of single-chain variable fragments (scFv) targeting CD4-induced epitopes

BACKGROUND: The CD4-induced (CD4i) epitopes in gp120 includes the co-receptor binding site, which are formed and exposed after interaction with CD4. Monoclonal antibodies (mAbs) to the CD4i epitopes exhibit limited neutralizing activity because of restricted access to their epitopes. However, small...

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Detalhes bibliográficos
Publicado no:Retrovirology
Main Authors: Tanaka, Kazuki, Kuwata, Takeo, Alam, Muntasir, Kaplan, Gilad, Takahama, Shokichi, Valdez, Kristel Paola Ramirez, Roitburd-Berman, Anna, Gershoni, Jonathan M., Matsushita, Shuzo
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2017
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5610415/
https://ncbi.nlm.nih.gov/pubmed/28938888
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12977-017-0369-y
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