Glutaminase 2 expression is associated with regional heterogeneity of 5-aminolevulinic acid fluorescence in glioblastoma

Fluorescence-guided surgery using 5-aminolevulinic acid (5-ALA) is now a widely-used modality for glioblastoma (GBM) treatment. However, intratumoral heterogeneity of fluorescence intensity may reflect different onco-metabolic programs. Here, we investigated the metabolic mechanism underlying the he...

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Udgivet i:Sci Rep
Main Authors: Kim, Sojin, Kim, Ja Eun, Kim, Yong Hwy, Hwang, Taeyoung, Kim, Sung Kwon, Xu, Wen Jun, Shin, Jong-Yeon, Kim, Jong-Il, Choi, Hyoungseon, Kim, Hee Chan, Cho, Hye Rim, Choi, Anna, Chowdhury, Tamrin, Seo, Youngbeom, Dho, Yun-Sik, Kim, Jin Wook, Kim, Dong Gyu, Park, Sung-Hye, Kim, Hyeonjin, Choi, Seung Hong, Park, Sunghyouk, Lee, Se-Hoon, Park, Chul-Kee
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2017
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5610329/
https://ncbi.nlm.nih.gov/pubmed/28939850
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-12557-3
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