The Histone H3K27 Demethylase UTX Regulates Synaptic Plasticity and Cognitive Behaviors in Mice

Histone demethylase UTX mediates removal of repressive trimethylation of histone H3 lysine 27 (H3K27me3) to establish a mechanistic switch to activate large sets of genes. Mutation of Utx has recently been shown to be associated with Kabuki syndrome, a rare congenital anomaly syndrome with dementia....

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Veröffentlicht in:Front Mol Neurosci
Hauptverfasser: Tang, Gang-Bin, Zeng, Yu-Qiang, Liu, Pei-Pei, Mi, Ting-Wei, Zhang, Shuang-Feng, Dai, Shang-Kun, Tang, Qing-Yuan, Yang, Lin, Xu, Ya-Jie, Yan, Hai-Liang, Du, Hong-Zhen, Teng, Zhao-Qian, Zhou, Feng-Quan, Liu, Chang-Mei
Format: Artigo
Sprache:Inglês
Veröffentlicht: Frontiers Media S.A. 2017
Schlagworte:
Neuroscience
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5609596/
https://ncbi.nlm.nih.gov/pubmed/28970783
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fnmol.2017.00267
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