Biscarbamate Cross-Linked Low-Molecular-Weight Polyethylenimine for Delivering Anti-chordin siRNA into Human Mesenchymal Stem Cells for Improving Bone Regeneration

Small-interfering RNA (siRNA) provides a rapid solution for drug design and provides new methods to develop customizable medicines. Polyethyleneimine 25 kDa (PEI25kDa) is an effective transfection agent used in siRNA delivery. However, the lack of degradable linkage causes undesirable toxicity, hind...

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Vydáno v:Front Pharmacol
Hlavní autoři: Wang, Chuandong, Yuan, Weien, Xiao, Fei, Gan, Yaokai, Zhao, Xiaotian, Zhai, Zhanjing, Zhao, Xiaoying, Zhao, Chen, Cui, Penglei, Jin, Tuo, Chen, Xiaodong, Zhang, Xiaoling
Médium: Artigo
Jazyk:Inglês
Vydáno: Frontiers Media S.A. 2017
Témata:
Pharmacology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5609535/
https://ncbi.nlm.nih.gov/pubmed/28970797
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2017.00572
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