Biscarbamate Cross-Linked Low-Molecular-Weight Polyethylenimine for Delivering Anti-chordin siRNA into Human Mesenchymal Stem Cells for Improving Bone Regeneration

Small-interfering RNA (siRNA) provides a rapid solution for drug design and provides new methods to develop customizable medicines. Polyethyleneimine 25 kDa (PEI25kDa) is an effective transfection agent used in siRNA delivery. However, the lack of degradable linkage causes undesirable toxicity, hind...

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Bibliographic Details
Published in:Front Pharmacol
Main Authors: Wang, Chuandong, Yuan, Weien, Xiao, Fei, Gan, Yaokai, Zhao, Xiaotian, Zhai, Zhanjing, Zhao, Xiaoying, Zhao, Chen, Cui, Penglei, Jin, Tuo, Chen, Xiaodong, Zhang, Xiaoling
Format: Artigo
Language:Inglês
Published: Frontiers Media S.A. 2017
Subjects:
Pharmacology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5609535/
https://ncbi.nlm.nih.gov/pubmed/28970797
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2017.00572
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