Genetic Predisposition to Multiple Myeloma at 5q15 Is Mediated by an ELL2 Enhancer Polymorphism

Multiple myeloma (MM) is a malignancy of plasma cells. Genome-wide association studies have shown that variation at 5q15 influences MM risk. Here, we have sought to decipher the causal variant at 5q15 and the mechanism by which it influences tumorigenesis. We show that rs6877329 G > C resides in...

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Publicado no:Cell Rep
Main Authors: Li, Ni, Johnson, David C., Weinhold, Niels, Kimber, Scott, Dobbins, Sara E., Mitchell, Jonathan S., Kinnersley, Ben, Sud, Amit, Law, Philip J., Orlando, Giulia, Scales, Matthew, Wardell, Christopher P., Försti, Asta, Hoang, Phuc H., Went, Molly, Holroyd, Amy, Hariri, Fadi, Pastinen, Tomi, Meissner, Tobias, Goldschmidt, Hartmut, Hemminki, Kari, Morgan, Gareth J., Kaiser, Martin, Houlston, Richard S.
Formato: Artigo
Idioma:Inglês
Publicado em: Cell Press 2017
Assuntos:
Report
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5608969/
https://ncbi.nlm.nih.gov/pubmed/28903037
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2017.08.062
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