Genetic Predisposition to Multiple Myeloma at 5q15 Is Mediated by an ELL2 Enhancer Polymorphism

Multiple myeloma (MM) is a malignancy of plasma cells. Genome-wide association studies have shown that variation at 5q15 influences MM risk. Here, we have sought to decipher the causal variant at 5q15 and the mechanism by which it influences tumorigenesis. We show that rs6877329 G > C resides in...

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Hlavní autoři: Ni Li, David C. Johnson, Niels Weinhold, Scott Kimber, Sara E. Dobbins, Jonathan S. Mitchell, Ben Kinnersley, Amit Sud, Philip J. Law, Giulia Orlando, Matthew Scales, Christopher P. Wardell, Asta Försti, Phuc H. Hoang, Molly Went, Amy Holroyd, Fadi Hariri, Tomi Pastinen, Tobias Meissner, Hartmut Goldschmidt, Kari Hemminki, Gareth J. Morgan, Martin Kaiser, Richard S. Houlston
Médium: Artigo
Jazyk:Inglês
Vydáno: Elsevier 2017-09-01
Edice:Cell Reports
Témata:
cancer genetics
genome-wide association studies
multiple myeloma
single nucleotide polymorphisms
On-line přístup:http://www.sciencedirect.com/science/article/pii/S2211124717311877
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