Bioenergetic state regulates innate inflammatory responses through the transcriptional co-repressor CtBP

The innate inflammatory response contributes to secondary injury in brain trauma and other disorders. Metabolic factors such as caloric restriction, ketogenic diet, and hyperglycemia influence the inflammatory response, but how this occurs is unclear. Here, we show that glucose metabolism regulates...

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Udgivet i:Nat Commun
Main Authors: Shen, Yiguo, Kapfhamer, David, Minnella, Angela M., Kim, Ji-Eun, Won, Seok Joon, Chen, Yanting, Huang, Yong, Low, Ley Hian, Massa, Stephen M., Swanson, Raymond A.
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2017
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5608947/
https://ncbi.nlm.nih.gov/pubmed/28935892
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-017-00707-0
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