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Novel scaffolds for inhibition of Cruzipain identified from high-throughput screening of anti-kinetoplastid chemical boxes

American Trypanosomiasis or Chagas disease is a prevalent, neglected and serious debilitating illness caused by the kinetoplastid protozoan parasite Trypanosoma cruzi. The current chemotherapy is limited only to nifurtimox and benznidazole, two drugs that have poor efficacy in the chronic phase and...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Salas-Sarduy, Emir, Landaburu, Lionel Urán, Karpiak, Joel, Madauss, Kevin P., Cazzulo, Juan José, Agüero, Fernán, Alvarez, Vanina Eder
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5608908/
https://ncbi.nlm.nih.gov/pubmed/28935948
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-12170-4
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