An engineered bispecific DNA-encoded IgG antibody protects against Pseudomonas aeruginosa in a pneumonia challenge model

The impact of broad-spectrum antibiotics on antimicrobial resistance and disruption of the beneficial microbiome compels the urgent investigation of bacteria-specific approaches such as antibody-based strategies. Among these, DNA-delivered monoclonal antibodies (DMAbs), produced by muscle cells in v...

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Publicado no:Nat Commun
Main Authors: Patel, Ami, DiGiandomenico, Antonio, Keller, Ashley E., Smith, Trevor R. F., Park, Daniel H., Ramos, Stephanie, Schultheis, Katherine, Elliott, Sarah T. C., Mendoza, Janess, Broderick, Kate E., Wise, Megan C., Yan, Jian, Jiang, Jingjing, Flingai, Seleeke, Khan, Amir S., Muthumani, Kar, Humeau, Laurent, Cheng, Lily I., Wachter-Rosati, Leslie, Stover, C. Kendall, Sardesai, Niranjan Y., Weiner, David B.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5608701/
https://ncbi.nlm.nih.gov/pubmed/28935938
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-017-00576-7
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