Fully human CD19-specific chimeric antigen receptors for T-cell therapy

Impressive results have been achieved by adoptively transferring T-cells expressing CD19-specific CARs with binding domains from murine mAbs to treat B-cell malignancies. T-cell mediated immune responses specific for peptides from the murine scFv antigen-binding domain of the CAR can develop in pati...

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Detalhes bibliográficos
Publicado no:Leukemia
Main Authors: Sommermeyer, Daniel, Hill, Tyler, Shamah, Steven M, Salter, Alexander I, Chen, Yan, Mohler, Kendall M., Riddell, Stanley R.
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5608623/
https://ncbi.nlm.nih.gov/pubmed/28202953
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/leu.2017.57
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