Formyl peptide derived lipopeptides disclose differences between the receptors in mouse and men and call the pepducin concept in question

A pepducin is a lipopeptide containing a peptide sequence that is identical to one of the intracellular domains of the G-protein coupled receptor (GPCR) assumed to be the target. Neutrophils express two closely related formyl peptide receptors belonging to the family of GPCRs; FPR1 and FPR2 in human...

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Veröffentlicht in:PLoS One
Hauptverfasser: Winther, Malene, Holdfeldt, André, Sundqvist, Martina, Rajabkhani, Zahra, Gabl, Michael, Bylund, Johan, Dahlgren, Claes, Forsman, Huamei
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2017
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Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5608352/
https://ncbi.nlm.nih.gov/pubmed/28934373
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0185132
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