Generation of a pancreatic cancer model using a Pdx1-Flp recombinase knock-in allele

The contribution of the tumor microenvironment to the development of pancreatic adenocarcinoma (PDAC) is unclear. The LSL-Kras(G12D/+);LSL-p53(R172H/+);Pdx-1-Cre (KPC) tumor model, which is widely utilized to faithfully recapitulate human pancreatic cancer, depends on Cre-mediated recombination in t...

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Bibliografske podrobnosti
izdano v:PLoS One
Main Authors: Wu, Jinghai, Liu, Xin, Nayak, Sunayana G., Pitarresi, Jason R., Cuitiño, Maria C., Yu, Lianbo, Hildreth, Blake E., Thies, Katie A., Schilling, Daniel J., Fernandez, Soledad A., Leone, Gustavo, Ostrowski, Michael C.
Format: Artigo
Jezik:Inglês
Izdano: Public Library of Science 2017
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5608307/
https://ncbi.nlm.nih.gov/pubmed/28934293
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0184984
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