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Generation of a pancreatic cancer model using a Pdx1-Flp recombinase knock-in allele
The contribution of the tumor microenvironment to the development of pancreatic adenocarcinoma (PDAC) is unclear. The LSL-Kras(G12D/+);LSL-p53(R172H/+);Pdx-1-Cre (KPC) tumor model, which is widely utilized to faithfully recapitulate human pancreatic cancer, depends on Cre-mediated recombination in t...
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| Publicado no: | PLoS One |
|---|---|
| Main Authors: | , , , , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Public Library of Science
2017
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5608307/ https://ncbi.nlm.nih.gov/pubmed/28934293 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0184984 |
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