HLA-DR7 and HLA-DQ2: Transgenic mouse strains tested as a model system for ximelagatran hepatotoxicity

The oral thrombin inhibitor ximelagatran was withdrawn in the late clinical trial phase because it adversely affected the liver. In approximately 8% of treated patients, drug-induced liver injury (DILI) was expressed as transient alanine transaminase (ALT) elevations. No evidence of DILI had been re...

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Bibliographische Detailangaben
Veröffentlicht in:PLoS One
Hauptverfasser: Lundgren, Hanna, Martinsson, Klara, Cederbrant, Karin, Jirholt, Johan, Mucs, Daniel, Madeyski-Bengtson, Katja, Havarinasab, Said, Hultman, Per
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2017
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5608249/
https://ncbi.nlm.nih.gov/pubmed/28934241
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0184744
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