Complexin Binding to Membranes and Acceptor t-SNAREs Explains Its Clamping Effect on Fusion

Complexin-1 is a SNARE effector protein that decreases spontaneous neurotransmitter release and enhances evoked release. Complexin binds to the fully assembled four-helical neuronal SNARE core complex as revealed in competing molecular models derived from x-ray crystallography. Presently, it is uncl...

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Veröffentlicht in:Biophys J
Hauptverfasser: Zdanowicz, Rafal, Kreutzberger, Alex, Liang, Binyong, Kiessling, Volker, Tamm, Lukas K., Cafiso, David S.
Format: Artigo
Sprache:Inglês
Veröffentlicht: The Biophysical Society 2017
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Articles
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5607037/
https://ncbi.nlm.nih.gov/pubmed/28456331
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2017.04.002
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