Role of ADP receptors on platelets in the growth of ovarian cancer

We investigated the effect of platelets on ovarian cancer and the role of adenosine diphosphate (ADP) receptors (P2Y12 and P2Y1) on platelets in the growth of primary ovarian cancer tumors. We showed that in murine models of ovarian cancer, a P2Y12 inhibitor (ticagrelor) reduced tumor growth by 60%...

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Veröffentlicht in:Blood
Hauptverfasser: Cho, Min Soon, Noh, Kyunghee, Haemmerle, Monika, Li, Dan, Park, Hyun, Hu, Qianghua, Hisamatsu, Takeshi, Mitamura, Takashi, Mak, Sze Ling Celia, Kunapuli, Satya, Ma, Qing, Sood, Anil K., Afshar-Kharghan, Vahid
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society of Hematology 2017
Schlagworte:
Platelets and Thrombopoiesis
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5606004/
https://ncbi.nlm.nih.gov/pubmed/28679740
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2017-02-769893
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