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Systematic single-cell analysis provides new insights into heterogeneity and plasticity of the pancreas

BACKGROUND: Diabetes mellitus is characterized by loss or dysfunction of insulin-producing β-cells in the pancreas, resulting in failure of blood glucose regulation and devastating secondary complications. Thus, β-cells are currently the prime target for cell-replacement and regenerative therapy. Tr...

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Detalhes bibliográficos
Publicado no:Mol Metab
Main Authors: Tritschler, Sophie, Theis, Fabian J., Lickert, Heiko, Böttcher, Anika
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2017
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5605721/
https://ncbi.nlm.nih.gov/pubmed/28951822
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molmet.2017.06.021
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