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An autism spectrum disorder-related de novo mutation hotspot discovered in the GEF1 domain of Trio
The Rho guanine nucleotide exchange factor (RhoGEF) Trio promotes actin polymerization by directly activating the small GTPase Rac1. Recent studies suggest that autism spectrum disorder (ASD)-related behavioral phenotypes in animal models of ASD can be produced by dysregulation of Rac1’s control of...
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| Publicado no: | Nat Commun |
|---|---|
| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group UK
2017
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5605661/ https://ncbi.nlm.nih.gov/pubmed/28928363 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-017-00472-0 |
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