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Peripheral Autoimmune Regulator Induces Exhaustion of CD4(+) and CD8(+) Effector T Cells to Attenuate Autoimmune Diabetes in Non-Obese Diabetic Mice
Autoimmune regulator (Aire) is one of the most crucial genes expressed in the thymus, where it orchestrates the promiscuous expression and presentation of tissue-specific antigens during thymocyte selection. The presence of Aire-expressing cells outside the thymus points toward its plausible extrath...
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| Publicado no: | Front Immunol |
|---|---|
| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Frontiers Media S.A.
2017
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5605615/ https://ncbi.nlm.nih.gov/pubmed/28966617 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2017.01128 |
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