Phosphorylation of Suppressor of Hairless impedes its DNA-binding activity

Notch signalling activity governs cellular differentiation in higher metazoa, where Notch signals are transduced by the transcription factor CSL, called Suppressor of Hairless [Su(H)] in Drosophila. Su(H) operates as molecular switch on Notch target genes: within activator complexes, including intra...

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Veröffentlicht in:Sci Rep
Hauptverfasser: Nagel, Anja C., Auer, Jasmin S., Schulz, Adriana, Pfannstiel, Jens, Yuan, Zhenyu, Collins, Courtney E., Kovall, Rhett A., Preiss, Anette
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group UK 2017
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5605572/
https://ncbi.nlm.nih.gov/pubmed/28928428
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-11952-0
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