SIRT1/Adenosine Monophosphate-Activated Protein Kinase α Signaling Enhances Macrophage Polarization to an Anti-inflammatory Phenotype in Rheumatoid Arthritis

Macrophages are crucially involved in the pathogenesis of rheumatoid arthritis (RA). Macrophages of the M1 phenotype act as pro-inflammatory mediators in synovium, whereas those of the M2 phenotype suppress inflammation and promote tissue repair. SIRT1 is a class 3 histone deacetylase with anti-infl...

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Detalhes bibliográficos
Publicado no:Front Immunol
Main Authors: Park, So Youn, Lee, Sung Won, Lee, Sang Yeob, Hong, Ki Whan, Bae, Sun Sik, Kim, Koanhoi, Kim, Chi Dae
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2017
Assuntos:
Immunology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5605563/
https://ncbi.nlm.nih.gov/pubmed/28966618
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2017.01135
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