Tumour-derived PGD2 and NKp30-B7H6 engagement drives an immunosuppressive ILC2-MDSC axis

Group 2 innate lymphoid cells (ILC2s) are involved in human diseases, such as allergy, atopic dermatitis and nasal polyposis, but their function in human cancer remains unclear. Here we show that, in acute promyelocytic leukaemia (APL), ILC2s are increased and hyper-activated through the interaction...

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Publicado no:Nat Commun
Main Authors: Trabanelli, Sara, Chevalier, Mathieu F., Martinez-Usatorre, Amaia, Gomez-Cadena, Alejandra, Salomé, Bérengère, Lecciso, Mariangela, Salvestrini, Valentina, Verdeil, Grégory, Racle, Julien, Papayannidis, Cristina, Morita, Hideaki, Pizzitola, Irene, Grandclément, Camille, Bohner, Perrine, Bruni, Elena, Girotra, Mukul, Pallavi, Rani, Falvo, Paolo, Leibundgut, Elisabeth Oppliger, Baerlocher, Gabriela M., Carlo-Stella, Carmelo, Taurino, Daniela, Santoro, Armando, Spinelli, Orietta, Rambaldi, Alessandro, Giarin, Emanuela, Basso, Giuseppe, Tresoldi, Cristina, Ciceri, Fabio, Gfeller, David, Akdis, Cezmi A., Mazzarella, Luca, Minucci, Saverio, Pelicci, Pier Giuseppe, Marcenaro, Emanuela, McKenzie, Andrew N. J., Vanhecke, Dominique, Coukos, George, Mavilio, Domenico, Curti, Antonio, Derré, Laurent, Jandus, Camilla
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5605498/
https://ncbi.nlm.nih.gov/pubmed/28928446
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-017-00678-2
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