Tumour-derived PGD2 and NKp30-B7H6 engagement drives an immunosuppressive ILC2-MDSC axis

Group 2 innate lymphoid cells (ILC2s) are involved in human diseases, such as allergy, atopic dermatitis and nasal polyposis, but their function in human cancer remains unclear. Here we show that, in acute promyelocytic leukaemia (APL), ILC2s are increased and hyper-activated through the interaction...

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محفوظ في:
التفاصيل البيبلوغرافية
الحاوية / القاعدة:Nat Commun
المؤلفون الرئيسيون: Trabanelli, Sara, Chevalier, Mathieu F., Martinez-Usatorre, Amaia, Gomez-Cadena, Alejandra, Salomé, Bérengère, Lecciso, Mariangela, Salvestrini, Valentina, Verdeil, Grégory, Racle, Julien, Papayannidis, Cristina, Morita, Hideaki, Pizzitola, Irene, Grandclément, Camille, Bohner, Perrine, Bruni, Elena, Girotra, Mukul, Pallavi, Rani, Falvo, Paolo, Leibundgut, Elisabeth Oppliger, Baerlocher, Gabriela M., Carlo-Stella, Carmelo, Taurino, Daniela, Santoro, Armando, Spinelli, Orietta, Rambaldi, Alessandro, Giarin, Emanuela, Basso, Giuseppe, Tresoldi, Cristina, Ciceri, Fabio, Gfeller, David, Akdis, Cezmi A., Mazzarella, Luca, Minucci, Saverio, Pelicci, Pier Giuseppe, Marcenaro, Emanuela, McKenzie, Andrew N. J., Vanhecke, Dominique, Coukos, George, Mavilio, Domenico, Curti, Antonio, Derré, Laurent, Jandus, Camilla
التنسيق: Artigo
اللغة:Inglês
منشور في: Nature Publishing Group UK 2017
الموضوعات:
Article
الوصول للمادة أونلاين:https://ncbi.nlm.nih.gov/pmc/articles/PMC5605498/
https://ncbi.nlm.nih.gov/pubmed/28928446
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-017-00678-2
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