Fluoxetine ameliorates cartilage degradation in osteoarthritis by inhibiting Wnt/β-catenin signaling

Abnormal activation of the Wnt/β-catenin signaling is implicated in the osteoarthritis (OA) pathology. We searched for a pre-approved drug that suppresses abnormally activated Wnt/β-catenin signaling and has a potency to reduce joint pathology in OA. We introduced the TOPFlash reporter plasmid into...

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Vydáno v:PLoS One
Hlavní autoři: Miyamoto, Kentaro, Ohkawara, Bisei, Ito, Mikako, Masuda, Akio, Hirakawa, Akihiro, Sakai, Tadahiro, Hiraiwa, Hideki, Hamada, Takashi, Ishiguro, Naoki, Ohno, Kinji
Médium: Artigo
Jazyk:Inglês
Vydáno: Public Library of Science 2017
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5604944/
https://ncbi.nlm.nih.gov/pubmed/28926590
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0184388
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