ProNGF-p75NTR axis plays a proinflammatory role in inflamed joints: a novel pathogenic mechanism in chronic arthritis

OBJECTIVE: To identify the role of mature nerve growth factor (mNGF), its immature form proNGF and their receptors in arthritis inflammation. METHODS: Real-time PCR, western blot and ELISA were performed to evaluate NGF, proNGF, their receptor and cytokine expression in synovial tissue and cells of...

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Detalhes bibliográficos
Publicado no:RMD Open
Main Authors: Minnone, Gaetana, Soligo, Marzia, Caiello, Ivan, Prencipe, Giusi, Manni, Luigi, Marafon, Denise Pires, Magni-Manzoni, Silvia, Manzo, Antonio, Benedetti, Fabrizio De, Bracci-Laudiero, Luisa
Formato: Artigo
Idioma:Inglês
Publicado em: BMJ Publishing Group 2017
Assuntos:
Paediatric Rheumatology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5604749/
https://ncbi.nlm.nih.gov/pubmed/28955492
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/rmdopen-2017-000441
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