Roflumilast reverses CFTR-mediated ion transport dysfunction in cigarette smoke-exposed mice

BACKGROUND: Dysfunction in cystic fibrosis transmembrane conductance regulator (CFTR) can be elicited by cigarette smoke and is observed in patients with chronic bronchitis. We have previously demonstrated in human airway epithelial cell monolayers that roflumilast, a clinically approved phosphodies...

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Detalhes bibliográficos
Publicado no:Respir Res
Main Authors: Raju, S. Vamsee, Rasmussen, Lawrence, Sloane, Peter A., Tang, Li Ping, Libby, Emily Falk, Rowe, Steven M.
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2017
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5604356/
https://ncbi.nlm.nih.gov/pubmed/28923049
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12931-017-0656-0
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