Methylation of the Vitamin D Receptor (VDR) Gene, Together with Genetic Variation, Race, and Environment Influence the Signaling Efficacy of the Toll-Like Receptor 2/1-VDR Pathway

BACKGROUND: The disparity in prevalence of infectious diseases across the globe is common knowledge. Vitamin D receptor (VDR)-mediated toll-like receptor (TLR) 2/1 signaling produces antimicrobial peptides, which is critical as a first line of defense in innate immunity. Numerous studies disclosed t...

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Detalhes bibliográficos
Publicado no:Front Immunol
Main Authors: Meyer, Vanessa, Saccone, Donovan Sean, Tugizimana, Fidele, Asani, Furaha Florence, Jeffery, Tamsyn Jacki, Bornman, Liza
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2017
Assuntos:
Immunology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5603903/
https://ncbi.nlm.nih.gov/pubmed/28959253
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2017.01048
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