NAAG Peptidase Inhibitors Act via mGluR3: Animal Models of Memory, Alzheimer’s, and Ethanol Intoxication

Glutamate carboxypeptidase II (GCPII) inactivates the peptide neurotransmitter N-acetylaspartylglutamate (NAAG) following synaptic release. Inhibitors of GCPII increase extracellular NAAG levels and are efficacious in animal models of clinical disorders via NAAG activation of a group II metabotropic...

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Detalles Bibliográficos
Publicado en:Neurochem Res
Main Authors: Olszewski, Rafal T., Janczura, Karolina J., Bzdega, Tomasz, Der, Elise K., Venzor, Faustino, O’Rourke, Brennen, Hark, Timothy J., Craddock, Kirsten E., Balasubramanian, Shankar, Moussa, Charbel, Neale, Joseph H.
Formato: Artigo
Idioma:Inglês
Publicado: Springer US 2017
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Original Paper
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5603630/
https://ncbi.nlm.nih.gov/pubmed/28285415
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s11064-017-2181-4
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