A network integration approach for drug-target interaction prediction and computational drug repositioning from heterogeneous information

The emergence of large-scale genomic, chemical and pharmacological data provides new opportunities for drug discovery and repositioning. In this work, we develop a computational pipeline, called DTINet, to predict novel drug–target interactions from a constructed heterogeneous network, which integra...

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Udgivet i:Nat Commun
Main Authors: Luo, Yunan, Zhao, Xinbin, Zhou, Jingtian, Yang, Jinglin, Zhang, Yanqing, Kuang, Wenhua, Peng, Jian, Chen, Ligong, Zeng, Jianyang
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2017
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5603535/
https://ncbi.nlm.nih.gov/pubmed/28924171
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-017-00680-8
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