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Molecular mechanisms involved in the non-monotonic effect of bisphenol-a on Ca(2+) entry in mouse pancreatic β-cells

In regulatory toxicology, the dose-response relationship is a key element towards fulfilling safety assessments and satisfying regulatory authorities. Conventionally, the larger the dose, the greater the response, following the dogma “the dose makes the poison”. Many endocrine disrupting chemicals,...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Villar-Pazos, Sabrina, Martinez-Pinna, Juan, Castellano-Muñoz, Manuel, Alonso-Magdalena, Paloma, Marroqui, Laura, Quesada, Ivan, Gustafsson, Jan-Ake, Nadal, Angel
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2017
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5603522/
https://ncbi.nlm.nih.gov/pubmed/28924161
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-11995-3
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