Genome-wide in vivo screen identifies novel host regulators of metastatic colonization

Metastasis is the leading cause of death for cancer patients. This multi-stage process requires tumour cells to survive in the circulation, extravasate at distant sites, then proliferate; it involves contributions from both the tumour cell and tumour microenvironment (‘host’, which includes stromal...

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Publicat a:Nature
Autors principals: van der Weyden, Louise, Arends, Mark J., Campbell, Andrew D., Bald, Tobias, Wardle-Jones, Hannah, Griggs, Nicola, Velasco-Herrera, Martin Del Castillo, Tüting, Thomas, Sansom, Owen J., Karp, Natasha A., Clare, Simon, Gleeson, Diane, Ryder, Edward, Galli, Antonella, Tuck, Elizabeth, Cambridge, Emma L., Voet, Thierry, Macaulay, Iain C., Wong, Kim, Spiegel, Sarah, Speak, Anneliese O., Adams, David J.
Format: Artigo
Idioma:Inglês
Publicat: 2017
Matèries:
Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5603286/
https://ncbi.nlm.nih.gov/pubmed/28052056
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature20792
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