Genome-wide in vivo screen identifies novel host regulators of metastatic colonization

Metastasis is the leading cause of death for cancer patients. This multi-stage process requires tumour cells to survive in the circulation, extravasate at distant sites, then proliferate; it involves contributions from both the tumour cell and tumour microenvironment (‘host’, which includes stromal...

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Pubblicato in:Nature
Autori principali: van der Weyden, Louise, Arends, Mark J., Campbell, Andrew D., Bald, Tobias, Wardle-Jones, Hannah, Griggs, Nicola, Velasco-Herrera, Martin Del Castillo, Tüting, Thomas, Sansom, Owen J., Karp, Natasha A., Clare, Simon, Gleeson, Diane, Ryder, Edward, Galli, Antonella, Tuck, Elizabeth, Cambridge, Emma L., Voet, Thierry, Macaulay, Iain C., Wong, Kim, Spiegel, Sarah, Speak, Anneliese O., Adams, David J.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2017
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5603286/
https://ncbi.nlm.nih.gov/pubmed/28052056
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature20792
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