Impact of UGT1A1 gene polymorphisms on plasma dolutegravir trough concentrations and neuropsychiatric adverse events in Japanese individuals infected with HIV-1

BACKGROUND: Dolutegravir (DTG) is metabolized mainly by uridine diphosphate (UDP)-glucuronosyltransferase 1A1 (UGT1A1), and partly by cytochrome P450 3A (CYP3A). Therefore, we focused on UGT1A1 gene polymorphisms (*6 and *28) in Japanese individuals infected with human immunodeficiency virus (HIV)-1...

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Detalhes bibliográficos
Publicado no:BMC Infect Dis
Main Authors: Yagura, Hiroki, Watanabe, Dai, Kushida, Hiroyuki, Tomishima, Kosuke, Togami, Hiroaki, Hirano, Atsushi, Takahashi, Masaaki, Hirota, Kazuyuki, Ikuma, Motoko, Kasai, Daisuke, Nishida, Yasuharu, Yoshino, Munehiro, Yamazaki, Kunio, Uehira, Tomoko, Shirasaka, Takuma
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2017
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5603066/
https://ncbi.nlm.nih.gov/pubmed/28915895
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12879-017-2717-x
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