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Calcium/calmodulin-dependent protein kinase regulates the PINK1/Parkin and DJ-1 pathways of mitophagy during sepsis

During sepsis and shock states, mitochondrial dysfunction occurs. Consequently, adaptive mechanisms, such as fission, fusion, and mitophagy, are induced to eliminate damaged portions or entire dysfunctional mitochondria. The regulatory PINK1/Parkin and DJ-1 pathways are strongly induced by mitochond...

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Detalhes bibliográficos
Publicado no:FASEB J
Main Authors: Zhang, Xianghong, Yuan, Du, Sun, Qian, Xu, Li, Lee, Emma, Lewis, Anthony J., Zuckerbraun, Brian S., Rosengart, Matthew R.
Formato: Artigo
Idioma:Inglês
Publicado em: Federation of American Societies for Experimental Biology 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5602905/
https://ncbi.nlm.nih.gov/pubmed/28615325
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.201601096RRR
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