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Role of the P2 residue of human alpha 1-antitrypsin in determining target protease specificity
Alpha 1-antitrypsin (A1AT) is a serine protease inhibitor that mainly inhibits neutrophil elastase in the lungs. A variant of A1AT at the P1 position with methionine 358 to arginine (A1AT-Pittsburgh) is a rapid inhibitor of thrombin with greatly diminished anti-elastase activity. The P2 residue (pos...
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| Publicado en: | PLoS One |
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| Autores principales: | , , , |
| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
Public Library of Science
2017
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5602671/ https://ncbi.nlm.nih.gov/pubmed/28922398 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0185074 |
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