Investigating isoquinoline derivatives for inhibition of inhibitor of apoptosis proteins for ovarian cancer treatment

OBJECTIVE: To discover novel isoquinoline derivatives for inhibition of inhibitor of apoptosis proteins (IAP) for the treatment of ovarian cancer. METHODS: We first synthesized 533 isoquinoline derivatives, and screened them using CCK-8 to measure their antiproliferative activity. These compounds we...

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Bibliographic Details
Published in:Drug Des Devel Ther
Main Authors: Chen, Chen, Wu, Jie, Zhu, Pengfei, Xu, Congjian, Yao, Liangqing
Format: Artigo
Language:Inglês
Published: Dove Medical Press 2017
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Original Research
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5602439/
https://ncbi.nlm.nih.gov/pubmed/28979099
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/DDDT.S137608
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