The long noncoding RNA HULC promotes liver cancer by increasing the expression of the HMGA2 oncogene via sequestration of the microRNA-186

The long noncoding RNA highly up-regulated in liver cancer (HULC) is aberrantly elevated in hepatocellular carcinoma (HCC), and this up-regulation is crucial for HCC pathogenesis. However, the underlying mechanism in HULC up-regulation is poorly understood. We hypothesized that HULC might modulate t...

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Udgivet i:J Biol Chem
Main Authors: Wang, Yuan, Chen, Fuquan, Zhao, Man, Yang, Zhe, Li, Jiong, Zhang, Shuqin, Zhang, Weiying, Ye, Lihong, Zhang, Xiaodong
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2017
Fag:
Gene Regulation
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5602398/
https://ncbi.nlm.nih.gov/pubmed/28765279
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M117.783738
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