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The melanocortin signaling cAMP axis accelerates repair and reduces mutagenesis of platinum-induced DNA damage
Using primary melanocytes and HEK293 cells, we found that cAMP signaling accelerates repair of bi- and mono-functional platinum-induced DNA damage. Elevating cAMP signaling either by the agonistic MC1R ligand melanocyte stimulating hormone (MSH) or by pharmacologic cAMP induction by forskolin enhanc...
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| Publicado no: | Sci Rep |
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| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group UK
2017
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5601928/ https://ncbi.nlm.nih.gov/pubmed/28916831 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-12056-5 |
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