Discovery of AZD-2098 and AZD-1678, Two Potent and Bioavailable CCR4 Receptor Antagonists

[Image: see text] N-(5-Bromo-3-methoxypyrazin-2-yl)-5-chlorothiophene-2-sulfonamide 1 was identified as a hit in a CCR4 receptor antagonist high-throughput screen (HTS) of a subset of the AstraZeneca compound bank. As a hit with a lead-like profile, it was an excellent starting point for a CCR4 rece...

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Bibliografiset tiedot
Julkaisussa:ACS Med Chem Lett
Päätekijät: Kindon, Nicholas, Andrews, Glen, Baxter, Andrew, Cheshire, David, Hemsley, Paul, Johnson, Timothy, Liu, Yu-Zhen, McGinnity, Dermot, McHale, Mark, Mete, Antonio, Reuberson, James, Roberts, Bryan, Steele, John, Teobald, Barry, Unitt, John, Vaughan, Deborah, Walters, Iain, Stocks, Michael J.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: American Chemical Society 2017
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC5601455/
https://ncbi.nlm.nih.gov/pubmed/28947948
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.7b00315
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