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Understanding the Effect of Statins and Patient Adherence in Atherosclerosis via a Quantitative Systems Pharmacology Model Using a Novel, Hybrid, and Multi-Scale Approach

Background and Objective: Statins are one of the most prescribed drugs to treat atherosclerosis. They inhibit the hepatic HMG-CoA reductase, causing a reduction of circulating cholesterol and LDL levels. Statins have had undeniable success; however, the benefits of statin therapy crystallize only if...

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Опубликовано в: :Front Pharmacol
Главные авторы: Pichardo-Almarza, Cesar, Diaz-Zuccarini, Vanessa
Формат: Artigo
Язык:Inglês
Опубликовано: Frontiers Media S.A. 2017
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Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC5601395/
https://ncbi.nlm.nih.gov/pubmed/28955237
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2017.00635
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