Highly Potent and Selective New Diphenethylamines Interacting with the κ-Opioid Receptor: Synthesis, Pharmacology, and Structure–Activity Relationships

[Image: see text] We previously reported on a series of small molecules targeting the κ-opioid (KOP) receptor featuring a diphenethylamine scaffold and showed the promise of these ligands as effective analgesics with reduced liability for adverse effects. This study expands the structure–activity re...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Julkaisussa:J Med Chem
Päätekijät: Erli, Filippo, Guerrieri, Elena, Ben Haddou, Tanila, Lantero, Aquilino, Mairegger, Michael, Schmidhammer, Helmut, Spetea, Mariana
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: American Chemical Society 2017
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC5601360/
https://ncbi.nlm.nih.gov/pubmed/28825813
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jmedchem.7b00981
Tagit: Lisää tagi
Ei tageja, Lisää ensimmäinen tagi!

Samankaltaisia teoksia