Genetic progression in gastrointestinal stromal tumors: mechanisms and molecular interventions

Gastrointestinal stromal tumors (GISTs) are the most common sarcomas in humans. Constitutively activating mutations in the KIT or PDGFRA receptor tyrosine kinases are the initiating oncogenic events. Most metastatic GISTs respond dramatically to therapies with KIT/PDGFRA inhibitors. Asymptomatic and...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Li, Ke, Cheng, Haibo, Li, Zhang, Pang, Yuzhi, Jia, Xiaona, Xie, Feifei, Hu, Guohong, Cai, Qingping, Wang, Yuexiang
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2017
Assuntos:
Review
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5601165/
https://ncbi.nlm.nih.gov/pubmed/28947997
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.16014
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