Shortened Spadin Analogs Display Better TREK-1 Inhibition, In Vivo Stability and Antidepressant Activity

Depression is a devastating mental disorder that affects 20% of the population worldwide. Despite their proven efficacy, antidepressants present a delayed onset of action and serious adverse effects. Seven years ago, we described spadin (PE 12-28) as a promising endogenous peptide with antidepressan...

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Detalles Bibliográficos
Publicado en:Front Pharmacol
Autores principales: Djillani, Alaeddine, Pietri, Mariel, Moreno, Sébastien, Heurteaux, Catherine, Mazella, Jean, Borsotto, Marc
Formato: Artigo
Lenguaje:Inglês
Publicado: Frontiers Media S.A. 2017
Materias:
Pharmacology
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5601071/
https://ncbi.nlm.nih.gov/pubmed/28955242
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2017.00643
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