Kindlin-2 regulates the growth of breast cancer tumors by activating CSF-1-mediated macrophage infiltration

Interplay between tumor cells and host cells in the tumor microenvironment dictates the development of all cancers. In breast cancer, malignant cells educate host macrophages to adopt a pro-tumorigenic phenotype. In this study, we show how the integrin regulatory protein kindlin-2 (FERMT2) promotes...

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Udgivet i:Cancer Res
Main Authors: Sossey-Alaoui, Khalid, Pluskota, Elzbieta, Bialkowska, Katarzyna, Szpak, Dorota, Parker, Yvonne, Morrison, Chevaun D., Lindner, Daniel J., Schiemann, William P., Plow, Edward F.
Format: Artigo
Sprog:Inglês
Udgivet: 2017
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5600848/
https://ncbi.nlm.nih.gov/pubmed/28687620
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-16-2337
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