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Mendelian randomization analyses in cardiometabolic disease: challenges in evaluating causality

Mendelian randomization (MR) is a burgeoning field that involves the use of genetic variants to assess causal relationships between exposures and outcomes. MR studies can be straightforward; for example, genetic variants within or near the encoding locus that is associated with protein concentration...

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Bibliographische Detailangaben
Veröffentlicht in:Nat Rev Cardiol
Hauptverfasser: Holmes, Michael V, Ala-Korpela, Mika, Davey Smith, George
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2017
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5600813/
https://ncbi.nlm.nih.gov/pubmed/28569269
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nrcardio.2017.78
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