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CryoEM structure of MxB reveals a novel oligomerization interface critical for HIV restriction
Human dynamin–like, interferon-induced myxovirus resistance 2 (Mx2 or MxB) is a potent HIV-1 inhibitor. Antiviral activity requires both the amino-terminal region of MxB and protein oligomerization, each of which has eluded structural determination due to difficulties in protein preparation. We repo...
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| Publicado no: | Sci Adv |
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| Main Authors: | , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Association for the Advancement of Science
2017
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5600524/ https://ncbi.nlm.nih.gov/pubmed/28929138 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciadv.1701264 |
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